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KMID : 1007420110090020103
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Mood and Emotion
2011 Volume.9 No. 2 p.103 ~ p.108
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Korean Medication Algorithm Project for Bipolar Disorder 2010 : Rapid Cycling
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Lee Eun
Bahk Won-Myong
Yoon Bo-Hyun
Min Kyung-Jun
Kim Won
Shin Young-Chul
Joo Yeon-Ho
Seo Jeong-Seok
Ahn Yong-Min
Lee Jung-Goo
Kim Byung-Su
Jon Duk-In
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Abstract
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Objectives : Bipolar disorder is an illness with significant morbidity and mortality that contributes to disturb social function. Our objective for this study is to revise Korean Medication Algorithm Project for Bipolar Disorder 2006 for rapid cycling.
Methods : The questionnaires to survey the expert opinion of medication for rapid cycling were completed by the review committee consisting of 70 Korean expert psychiatrists. We classified the experts’ opinion to 3 categories based on the lowest category in which the confidence interval fall (6.5≤ for first-line and 3.5≤ for second-line treatment).
Results : The first-line treatment is the combination of a mood stabilizer and an atypical antipsychotic. Combination of two mood stabilizers was preferred as next strategy. The first-line medications in all cases are valproic acid, lithium, quetiapine, and olanzapine. For the treatment of depressive phase, lamotrigine is the first-line medication.
Conclusion : Compared to the surveys in 2006, the preference for lamotrigine and atypical antipsychotics has increased while that of carbamazepine and antidepressant has decreased.
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KEYWORD
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Bipolar disorder, Rapid cycling, Korean medication algorithm, Revision
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